U.S., Aug. 22 -- ClinicalTrials.gov registry received information related to the study (NCT07779811) titled 'Topical Metformin Versus Triple Regimen for Epidermal Melasma' on Aug. 06.
Brief Summary: Melasma is a common skin condition that causes dark brown patches, mainly on sun-exposed areas of the face. It is often persistent, may recur after treatment, and can affect a person's quality of life. The standard topical triple regimen used for melasma contains hydroquinone, tretinoin, and fluocinolone acetonide. Although effective, prolonged use may cause adverse effects such as redness, burning, peeling, telangiectasia, and steroid-related skin changes. Topical metformin has recently been investigated as a possible alternative treatment bec...