U.S., June 10 -- ClinicalTrials.gov registry received information related to the study (NCT07634562) titled 'TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation' on June 04.
Brief Summary: The unmet medical need in solid organ transplantation is to eliminate the lifelong requirement of powerful immune suppression drug combinations with their attendant side effects, and to prevent immune mediated rejection of the organ transplant. The proposed trial is designed to study if following a 'standard of care' deceased donor liver transplant host conditioning using Total Lymphoid Irradiation (TLI) and Anti-Tthymocyte Globulin (ATG) will result in operational tolerance and ultimately allow for immunosuppression drug minimization or ...