U.S., Nov. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07910552) titled 'The Immunobiological Mechanisms of Depression in Perimenopause' on Oct. 13.
Brief Summary: This project aims to identify immunobiological mechanisms underlying the development of depression during the perimenopause. During the perimenopause, the risk for recurrence of depression is increased 13-fold among women who previously had depression. Moreover, perimenopause overlaps with the age span exhibiting the highest suicide rate for women. The perimenopause can last for several years and starts when estrogen and progesterone levels begin to fluctuate, gradually declining. Sex hormones are powerful modulators of the immune response and ...