Clinical Trial: Study on Precision Dosing Strategies of Anti-infective Agents in the Very Early Stage of Kidney Transplantation

U.S., Aug. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07765615) titled 'Study on Precision Dosing Strategies of Anti-infective Agents in the Very Early Stage of Kidney Transplantation' on Aug. 11.

Brief Summary: This study addresses the clinical problem that reliance on serum creatinine, eGFR or empirical dosing fails to accurately adjust anti-infective doses given rapid renal function shifts within the very early 0-5 days post kidney transplantation. We will systematically analyze dynamic trajectories of renal biomarkers (serum creatinine, cystatin C, urine output and other renal function indices), quantify their quantitative associations with the exposure, clearance and pharmacodynamic target attainme...