Clinical Trial: Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation

U.S., June 12 -- ClinicalTrials.gov registry received information related to the study (NCT07642908) titled 'Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation' on May 13.

Brief Summary: This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the mutation (iPD). Participants will complete positron emission tomography (PET) and magnetic resonance imaging (MRI) brain imaging, cognitive tests, motor tests, sensory tests, and questionnaires. The aims of this study are to compare brain chemicals in LRRK2 PD patients with iPD patients and to correlate br...