Clinical Trial: Stereotactic Body Radiotherapy (SBRT) Induced Pancreatic Atrophy for Prevention of Post Operative Pancreatic Fistulae (POPF) After Pancreatoduodenectomy in Very High-Risk Patients (STEREOPANC)

U.S., Oct. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07884019) titled 'Stereotactic Body Radiotherapy (SBRT) Induced Pancreatic Atrophy for Prevention of Post Operative Pancreatic Fistulae (POPF) After Pancreatoduodenectomy in Very High-Risk Patients (STEREOPANC)' on Oct. 09.

Brief Summary: STEREOPANC is a randomized, controlled, open label, multicenter study initiated by the Oulu HPB Study Group. Patients with a very high risk of B/C POPF (soft pancreas) scheduled for PD for any indication are recognized at a local HPB MDT. Patients are randomized to either intervention arm (preoperative SBRT in 3 x 6,6Gy fractions = 19.8 Gy) or control arm (conventional treatment) with a ratio of 1:1. Participating c...