U.S., June 5 -- ClinicalTrials.gov registry received information related to the study (NCT07625930) titled 'RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial' on May 29.
Brief Summary: Esophageal and gastroesophageal junction cancers are serious diseases with limited cure rates, even when patients receive chemotherapy and surgery. New ways to improve treatment are urgently needed.
This study will test whether adding a commonly used cholesterol-lowering medication, simvastatin, to standard cancer treatment can improve outcomes. Simvastatin is widely used, safe, and inexpensive. Research suggests that it may also slow cancer growth by blocking pathways that cancer cells rely on for survival.
In this trial, ...