U.S., Feb. 28 -- ClinicalTrials.gov registry received information related to the study (NCT07437209) titled 'PRF + Minocycline vs Arestin in Non-surgical Perio Therapy' on Feb. 22.
Brief Summary: Periodontitis is a chronic, biofilm-modulated inflammatory disease characterized by microbial dysbiosis and a dysregulated host immune response, eventually resulting in the gradual breakdown of the periodontal attachment apparatus. While non-surgical periodontal therapy (NSPT) remains the first choice of treatment, its capability to completely resolve inflammation and pocketing in moderate disease severity may be limited, supporting the use of adjunctive antimicrobial or biologic interventions. Platelet-rich fibrin (PRF) and locally administered a...