Clinical Trial: Pathological Micro-Niches and Multimodal Imaging Macro-Niches for Predicting Clinically Significant Prostate Cancer and Metastasis: A Multicenter Study

U.S., Nov. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07936175) titled 'Pathological Micro-Niches and Multimodal Imaging Macro-Niches for Predicting Clinically Significant Prostate Cancer and Metastasis: A Multicenter Study' on Oct. 29.

Brief Summary: This is an investigator-initiated, multicenter, observational ambispective cohort study, predominantly retrospective, with an optional prospective non-interventional silent validation. The study tests a cross-scale hypothesis that the pathological micro-niche of the primary prostate tumor (tumor epithelium, invasive front, immune-rich or immune-poor regions, ECM/collagen remodeling, neurovascular neighborhoods, and peritumoral field effect) is associated a...