U.S., March 5 -- ClinicalTrials.gov registry received information related to the study (NCT07448935) titled 'One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS' on Feb. 26.
Brief Summary: By detailed sequence analysis and subsequent biophysical characterization of prototypic light chains, this project aims to identify sequence fingerprints in IGLV1-44 light chains leading to AL amyloidosis and POEMS syndrome. This understanding might help improve the risk stratification and early diagnosis of patients overexpressing pathologic IGLV1-44 LCs. Moreover, the development of nanobodies efficient in recognizing and stabilizing IGLV1-44 light chains which exert direct toxicity in cardiac AL amyloidosis and POEMS sy...