Clinical Trial: Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera

U.S., Sept. 1 -- ClinicalTrials.gov registry received information related to the study (NCT07795060) titled 'Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera' on Aug. 24.

Brief Summary: This Phase IIa randomized controlled trial will evaluate whether a single oral dose of ondansetron can reduce oral rehydration failure in children and adolescents with suspected or confirmed cholera and active vomiting. Approximately 120 participants aged 6 months to 17 years with no or some dehydration will be randomized 1:1 to receive standard cholera care alone or standard care plus oral ondansetron 0.15 mg/kg, up to a maximum dose of 8 mg. The primary outcome is oral rehydration failure within 6 hours, defined as initiation of cl...