U.S., July 17 -- ClinicalTrials.gov registry received information related to the study (NCT07707609) titled 'Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis' on July 13.
Brief Summary: Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology. Increasing evidence suggests that persistent pain is not solely driven by peripheral pancreatic abnormalities but also by central sensitization, involving maladaptive changes in central nervous system pain-processing pathways. While altered brain connectivity and neurochemical changes have been demonstrated in other chron...