U.S., June 23 -- ClinicalTrials.gov registry received information related to the study (NCT07660783) titled 'Naive T Cell Deplete Grafts for GVHD Prevention in Non-Malignant Diseases' on June 16.
Brief Summary: This phase II trial investigates how well a naive T cell depleted graft work for the reduction of graft versus host disease in patients with non-malignant diseases requiring hematopoietic cell transplantation. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cel...