Clinical Trial: Multicenter Randomized Controlled Trial of Probiotics Combined With Targeted Therapy Plus Immunotherapy in the Bladder-Preserving Setting for Patients With Muscle-Invasive Bladder Cancer

U.S., March 17 -- ClinicalTrials.gov registry received information related to the study (NCT07474064) titled 'Multicenter Randomized Controlled Trial of Probiotics Combined With Targeted Therapy Plus Immunotherapy in the Bladder-Preserving Setting for Patients With Muscle-Invasive Bladder Cancer' on March 10.

Brief Summary: The goal of this clinical trial is to learn if oral probiotics (Clostridium butyricum) work to improve the efficacy of targeted therapy plus immunotherapy in bladder preservation setting for cisplatin-ineligible T2-3N0M0 bladder cancer patients with low serum butyrate.

The main questions it aims to answer are: Does oral probiotics elevate serum butyrate levels and enhance the duation of bladder preservation interval wi...