U.S., March 11 -- ClinicalTrials.gov registry received information related to the study (NCT07460505) titled 'Mandibular Advancement to Reduce Ventricular Load and Improve Quality-of-life in Heart Failure' on Feb. 23.
Brief Summary: Heart failure with reduced ejection fraction (HFrEF) is a serious condition that limits daily activities and often leads to hospital stays and early death. Many patients with HFrEF also have obstructive sleep apnea (OSA), a common but often undiagnosed condition where breathing repeatedly stops during sleep. This causes drops in oxygen, poor sleep, and stress on the heart, which can make heart failure worse.
The investigators are studying whether a device called a mandibular advancement device (MAD)-a mouthpie...