U.S., Oct. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07874373) titled 'Magnesium Supplementation for the Prevention of Cisplatin-Induced Nephrotoxicity' on Oct. 08.
Brief Summary: This prospective, randomized, open-label study evaluated whether intravenous magnesium sulphate added to standard hydration could reduce cisplatin-associated renal toxicity in adult patients with solid tumors receiving weekly cisplatin-based chemoradiotherapy. Participants were assigned to standard hydration with intravenous saline and furosemide or to the same hydration protocol supplemented with 1 g of intravenous magnesium sulphate before cisplatin administration. The primary outcome was early renal toxicity assessed 48 ho...