Clinical Trial: Low- vs High-Dose Sirolimus With Prednisolone for KHE and KMP

U.S., June 19 -- ClinicalTrials.gov registry received information related to the study (NCT07656909) titled 'Low- vs High-Dose Sirolimus With Prednisolone for KHE and KMP' on June 15.

Brief Summary: This randomized clinical trial evaluates if low-dose sirolimus (target trough 4-8 ng/mL) combined with prednisolone is noninferior in efficacy but superior in safety compared to standard high-dose sirolimus (target trough 10-15 ng/mL) combined with prednisolone in pediatric patients with kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon (KHE with KMP), with participants randomized 1:1 to receive the assigned regimen, undergo routine blood and imaging monitoring, and be evaluated for clinical response and adverse events.

Study Sta...