Clinical Trial: Lamivudine as a Novel Clinical Effort for Rett Syndrome

U.S., June 11 -- ClinicalTrials.gov registry received information related to the study (NCT07640503) titled 'Lamivudine as a Novel Clinical Effort for Rett Syndrome' on May 12.

Brief Summary: Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder caused primarily by mutations in the MECP2 gene, leading to progressive impairments in motor function, communication, and behavior following an initial period of apparently typical development. Currently, there are no treatments that change the course of the disease, and clinical care is largely focused on managing symptoms. Loss of MeCP2 function has been associated with increased activity of the LINE-1 (L1) retroelement, which may contribute to neuroinflammation and cellular stress in...