Clinical Trial: Intranasal Insulin for Postoperative Delirium in Older Patients With T2DM

U.S., July 23 -- ClinicalTrials.gov registry received information related to the study (NCT07720479) titled 'Intranasal Insulin for Postoperative Delirium in Older Patients With T2DM' on June 08.

Brief Summary: Postoperative delirium (POD) is highly prevalent in older patients with type 2 diabetes mellitus (T2DM). Cerebral insulin resistance is considered a key pathophysiological mechanism underlying this association. This study aims to investigate whether intranasal insulin (INI) can prevent POD and early postoperative cognitive decline by improving cerebral insulin resistance. We will conduct a randomized, double-blind, placebo-controlled multicenter trial. Older T2DM patients will be randomly assigned to receive intranasal insulin at do...