U.S., June 19 -- ClinicalTrials.gov registry received information related to the study (NCT07656077) titled 'Intestinal Tissue-Resident Memory T Cells and HIV-1 Persistence During Antiretroviral Therapy' on June 10.
Brief Summary: The study aims to better characterize intestinal tissue-resident memory T cells (TRM) in people living with HIV-1 receiving suppressive antiretroviral therapy (ART). TRM cells are key components of tissue immunity and may contribute to HIV-1 persistence within the intestinal mucosa, a major viral reservoir. The phenotypic, transcriptomic, and functional characteristics of intestinal CD4+ and CD8+ TRM cells, their susceptibility to HIV-1 infection, and their potential role as viral reservoirs will be investigated....