U.S., March 7 -- ClinicalTrials.gov registry received information related to the study (NCT07455708) titled 'Impact of NR3C1 rs41423247 (BclI) Polymorphism on Disease Severity in Alopecia Areata' on March 03.
Brief Summary: Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response. The rs41423247 polymorphism (BclI) may influence glucocorticoid sensitivity and disease activity. This study aims to investigate the association between NR3C1 rs41423247 polymorphism and susceptibility to alopecia areata and to evaluate its correlation with disease severity using the Severity of Alopecia Tool (...