U.S., April 16 -- ClinicalTrials.gov registry received information related to the study (NCT07531420) titled 'Impact of Antibiotic Prophylaxis Change on Surgical Site Infections After Pancreaticoduodenectomy' on April 09.
Brief Summary: Patients undergoing pancreaticoduodenectomy after preoperative biliary drainage are at increased risk of surgical site infections (SSI) due to bile colonization. Recent guidelines recommend the use of piperacillin/tazobactam instead of cephalosporins for antibiotic prophylaxis in this population. However, the relevance of this strategy may depend on local microbiological ecology.
This monocentric ambispective cohort study aims to compare SSI rates between two periods: before and after implementation of pip...