U.S., July 10 -- ClinicalTrials.gov registry received information related to the study (NCT07693270) titled 'Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery' on July 02.
Brief Summary: The mechanisms leading to opioid tolerance or dependence are not well understood and there are currently no biomarkers for predicting who is at risk for development of OUD. The purpose of this project is to support the feasibility of detecting a miRNA bio-behavioral signature of opioid misuse risk that will demonstrate improved predictive precision compared to current tools such as polygenic risk scores (PRS). Specifically, the study will address key goals of the Wellcome Leap program to develop scalable ...