Clinical Trial: Hypothalamic GLP-1 Response in Healthy Weight and Obesity

U.S., Oct. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07854886) titled 'Hypothalamic GLP-1 Response in Healthy Weight and Obesity' on Sept. 17.

Brief Summary: The goal of this clinical trial is to learn how the gut hormone glucagon-like peptide-1 (GLP-1) helps the brain sense sugar. It includes adults with healthy weight and adults with obesity.

The main questions this trial aims to answer are:

A. Does GLP-1 cause the brain's response to sugar? B. Do lower GLP-1 levels cause a weaker brain response to sugar in adults with obesity?

Researchers will compare each participant's brain response across four test days. On these days, GLP-1 levels will be blocked, raised, or left unchanged. Sugar will be given...