U.S., April 4 -- ClinicalTrials.gov registry received information related to the study (NCT07510607) titled 'Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis' on March 26.
Brief Summary: The main purpose of this study is to assess whether hyperpolarized carbon imaging in relapsing remitting multiple sclerosis (MS) patients can be used to predict response to anti-CD20 disease modifying therapy. Study procedures will include magnetic resonance imaging (MRI) assessments with a hyperpolarized pyruvate sequence, clinical assessment as well as blood markers of disease progression.
This method of imaging utilizes the Warburg effect, where innate immune cells utilize a metabolic shift to glycolysis instead of oxidative phosphorylatio...