U.S., March 13 -- ClinicalTrials.gov registry received information related to the study (NCT07466108) titled 'Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy' on March 08.
Brief Summary: Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, p...