Clinical Trial: Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial

U.S., Oct. 16 -- ClinicalTrials.gov registry received information related to the study (NCT07875686) titled 'Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial' on May 08, 2025.

Brief Summary: Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not. It is hypothesized that a complete full thickness myotomy could lead to higher rates of gastroesophageal reflux disease (GERD). In this study we compare performing a Full-thickness myotomy with a progressive myotomy (proximal half circular only, dista...