U.S., March 25 -- ClinicalTrials.gov registry received information related to the study (NCT07490353) titled 'Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects' on Nov. 17, 2025.
Brief Summary: The goal of this clinical trial is to systematically categorize potential prohedonic effects of psilocybin in patients with anhedonia in depression. The main questions it aims to answer are:
Primary Objectives
1. Systematically categorize prohedonic effects (antianhedonic effects in patients with anhedonia in depression, increase in well-being in all participants).
2. Test effects of psilocybin on brain network complexity measures during the hedonic experience using fMRI as a correlate for prohedonic (...