U.S., Aug. 18 -- ClinicalTrials.gov registry received information related to the study (NCT07768618) titled 'Electrophysiologic Mechanisms of Ketamine Antidepressant Response' on Aug. 12.
Brief Summary: This study aims to identify electrophysiologic biomarkers associated with antidepressant response to ketamine in adults with epilepsy undergoing clinically indicated stereo-electroencephalography (sEEG) monitoring who have at least mild depressive symptoms.
Participants will receive a single subanesthetic intravenous ketamine infusion (0.5 mg/kg over 40 minutes) during their Epilepsy Monitoring Unit admission. Intracranial neural recordings and behavioral assessments will be collected before and approximately 24 hours after infusion to exa...