U.S., March 17 -- ClinicalTrials.gov registry received information related to the study (NCT07472309) titled 'Effectiveness and Safety of Upadacitinib for Acute Severe Ulcerative Colitis' on March 04.
Brief Summary: The aim of this retrospective observational study is to investigate and compare the real-world effectiveness and safety of upadacitinib when used as first-line exposure versus rescue exposure in patients with acute severe ulcerative colitis (ASUC).
The key questions to be addressed are:
In patients with ASUC, does upadacitinib administered as first-line induction exposure result in higher rates of colectomy-free survival, clinical remission, and endoscopic healing compared with its use as rescue exposure following failure of ...