Clinical Trial: Effect of Cholecalciferol on Mucin-1 Levels in Urinary Extracelllular Vesicles in Individuals With Autosomal Dominant Tubulo-Interstitial Kidney Disease Due to MUC1 Mutations (ADTKD-MUC1)

U.S., Oct. 30 -- ClinicalTrials.gov registry received information related to the study (NCT07903909) titled 'Effect of Cholecalciferol on Mucin-1 Levels in Urinary Extracelllular Vesicles in Individuals With Autosomal Dominant Tubulo-Interstitial Kidney Disease Due to MUC1 Mutations (ADTKD-MUC1)' on Oct. 07.

Brief Summary: Autosomal dominant tubulointerstitial kidney disease due to MUC1 mutations (ADTKD-MUC1) is caused by mutations in the MUC1 gene encoding the protein mucin-1. The most frequently reported mutation is a cytosine insertion causing a frameshift and resulting in the production of an abnormal protein (MUC1-fs). The primary characteristic of ADTKD-MUC1 is slowly progressive chronic kidney disease, with age-dependent progression...