U.S., April 22 -- ClinicalTrials.gov registry received information related to the study (NCT07542730) titled 'Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions' on April 10.
Brief Summary: This single center, double blind, randomized controlled trial will evaluate whether adding intravenous diphenhydramine to a standard moderate sedation regimen improves pain control during first trimester procedural abortion. Participants undergoing uterine aspiration at less than 13 weeks gestation will be randomized 1 to 1 to receive standard moderate sedation with midazolam and fentanyl plus either diphenhydramine 50 mg intravenously or matching placebo. The primary outcome is participant reported pain during u...