U.S., May 19 -- ClinicalTrials.gov registry received information related to the study (NCT07592611) titled 'Deep Brain Stimulation for Treatment-Resistant Schizophrenia' on May 12.
Brief Summary: The purpose of this pilot study is to investigate the use of deep brain stimulation (DBS) of the substantia nigra pars reticulata (SNr) in subjects with treatment-resistant schizophrenia. There is a subset of patients with schizophrenia who continue to have persistent psychotic symptoms (auditory hallucinations and delusions) despite multiple adequate medication trials with antipsychotic medications including clozapine. There are currently no available treatments for such patients who generally have poor function and are chronically disabled, unab...