Clinical Trial: Cross Immune Response Between Breast Carcinoma and Thyroid Autoimmunity: Impact on Prognosis and Treatment

U.S., Oct. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07870148) titled 'Cross Immune Response Between Breast Carcinoma and Thyroid Autoimmunity: Impact on Prognosis and Treatment' on Oct. 06.

Brief Summary: Background: Patients with breast cancer (BC) seem to have a higher prevalence of thyroid autoimmunity (TA), and this association has a solid pathogenic rationale: 1) I have discovered that BC tissue expresses thyroid peroxidase (TPO), a major thyroid autoantigen which exists in different isoforms by alternative splicing; 2) the immune system has a key role in both autoimmunity and cancer; 3) immunity and gut microbiota are deeply connected. Serum anti-TPO autoantibodies (TPOAb), the hallmark of TA, a...