U.S., May 13 -- ClinicalTrials.gov registry received information related to the study (NCT07580339) titled 'Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer' on May 05.
Brief Summary: The purpose of this study is to evaluate the safety and clinical activity of combining DCSZ11 with radiation and capecitabine/oxaliplatin (CAPOX) for the neoadjuvant treatment of patients with mismatch repair proficient (pMMR) high risk locally advanced rectal cancer.
Study Start Date: July, 2026
Study Type: INTERVENTIONAL
Condition:
Rectal Cancer
Intervention:
DRUG: DCSZ11
Patients will receive a lead in dose of DCSZ11 (1200 mg administered IV). Three weeks after the lead-in dose, DCSZ11...