U.S., March 14 -- ClinicalTrials.gov registry received information related to the study (NCT07469371) titled 'CLEAR-AS: CT-FFR-Guided Revascularization in Patients With Severe Aortic Stenosis' on March 09.
Brief Summary: Severe aortic stenosis (AS) is often accompanied by coronary artery disease (CAD). While coronary computed tomography angiography (CCTA) is routinely used before aortic valve replacement (AVR) to evaluate coronary anatomy, it lacks physiological assessment of myocardial ischemia.
This prospective, single-center, randomized controlled trial aims to evaluate whether integrating functional assessment using CT-derived fractional flow reserve (CT-FFR) with CCTA can optimize revascularization decision-making and improve clinica...