U.S., March 19 -- ClinicalTrials.gov registry received information related to the study (NCT07480460) titled 'Brain and Gene Expression Responses to Exercise in Chronic Back Pain' on March 14.
Brief Summary: This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating frontostriatal brain connectivity and immune-related gene expression. Fifty-seven adults with CLBP were randomized to exercise training or wait-list control. Participants underwent pre- and post-intervention MRI, questionnaires, and blood sampling. The study tested whether reductions in nucleus accumbens-medial ...