U.S., April 14 -- ClinicalTrials.gov registry received information related to the study (NCT07523529) titled 'Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid Tumors' on April 05.
Brief Summary: This is a multicenter, open-label, Phase 1/2 master protocol evaluating autologous dual-target CAR-T cell therapy in adults with advanced solid cancers. After central biomarker screening, each participant is assigned the best-matched dual-target construct from a predefined target-pair library. The trial is designed to test whether biomarkerguided dual targeting can improve tumor control, reduce antigenescape risk, and preserve safety in solid tumors.
Study Start Date: March 02
Study Type: INTERVENTIONAL
Condition:
Advanced Unresectab...