Clinical Trial: An Open-label, Non-randomised Safety and Tolerability Proof of Concept Trial to Examine Multiple Dosing Addition of Glycocholate (GC) and Butyrate (B) to Increase Calcium Absorption in Healthy Participants That Have Undergone Roux-en-Y Gastric Bypass (BAFA)

U.S., Nov. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07935811) titled 'An Open-label, Non-randomised Safety and Tolerability Proof of Concept Trial to Examine Multiple Dosing Addition of Glycocholate (GC) and Butyrate (B) to Increase Calcium Absorption in Healthy Participants That Have Undergone Roux-en-Y Gastric Bypass (BAFA)' on Aug. 13.

Brief Summary: To improve calcium homeostasis after Roux-en-Y gastric bypass (RYGB), we hypothesize that oral administration of a liquid formulation containing the bile acid glycocholate (GC) and the short-chain fatty acid butyrate (B) may synergistically enhance intestinal calcium absorption (Casselbrant et al., 2020). When administered at physiological doses three ...