Clinical Trial: An Open-Label, Investigator-Initiated Study Evaluating the Use of Upadacitinib in Patients Hospitalized With Acute Severe Ulcerative Colitis

U.S., April 1 -- ClinicalTrials.gov registry received information related to the study (NCT07502339) titled 'An Open-Label, Investigator-Initiated Study Evaluating the Use of Upadacitinib in Patients Hospitalized With Acute Severe Ulcerative Colitis' on March 25.

Brief Summary: The goal of this clinical trial is to learn if the oral medication upadacitinib can safely and effectively treat acute severe ulcerative colitis (ASUC) in adults who are hospitalized. It will also evaluate whether upadacitinib can be used without corticosteroids during initial treatment.

The main questions it aims to answer are:

1. Does upadacitinib reduce treatment failure by Day 14 (defined as need for colectomy or rescue therapy)?

2. What side effects and safe...