U.S., March 19 -- ClinicalTrials.gov registry received information related to the study (NCT07479537) titled 'Acquired Tick Resistance in Naturally Exposed Participants' on Dec. 03, 2025.
Brief Summary: Tick-borne diseases are increasing worldwide, and there are currently few effective ways to prevent them. One promising new strategy is to develop a vaccine that targets the tick itself ("anti-tick vaccine") to block the transmission of multiple pathogens. Some animals naturally develop resistance to ticks after repeated tick bites. There are indications that a similar form of acquired tick resistance (ATR) may also occur in humans who have been heavily exposed to ticks. This study investigates whether humans can naturally develop tick resi...