Clinical Trial: A Phase I Study of SY-9453 in Patients With Advanced Solid Tumors

U.S., March 14 -- ClinicalTrials.gov registry received information related to the study (NCT07469982) titled 'A Phase I Study of SY-9453 in Patients With Advanced Solid Tumors' on March 03.

Brief Summary: This is an open-label, single-arm, multicenter, dose-escalation and dose-expansion, phase I study to the safety, tolerability, pharmacokinetics, and preliminary efficacy of SY-9453 in patients with advanced solid tumors.

Study Start Date: Feb., 2026

Study Type: INTERVENTIONAL

Condition: Advanced or Metastatic Solid Tumors With Homozygous MTAP Deletion

Intervention: DRUG: SY-9453

Dose-escalation phase: Multiple doses of SY-9453 for oral administration ranging from 5mg to 80mg.

Dose-expansion phase: RDEs of SY-5007 asdetermined duri...