Clinical Trial: A Phase 1, First-in-human Study of VX-433

U.S., May 14 -- ClinicalTrials.gov registry received information related to the study (NCT07584434) titled 'A Phase 1, First-in-human Study of VX-433' on May 06.

Brief Summary: The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of VX-433 following single and multiple ascending doses, as well as to assess the effect of VX-433 on the PK of midazolam, bupropion, and hydroxybupropion.

Study Start Date: May 12

Study Type: INTERVENTIONAL

Condition: Narcolepsy Type 1 (NT1)

Intervention: DRUG: VX-433

Suspension for Oral Administration

DRUG: Placebo

Suspension for Oral Administration

DRUG: Midazolam

Syrup for Oral Administration

DRUG: Bupropion

Capsule for Oral Administration

Recruitment Statu...