UNIVERSITY PARK, Pa., Sept. 14 -- Pennsylvania State University issued the following news release:
UNIVERSITY PARK, Pa. - A new 3D-structure of a cancer-linked protein bound to its cellular partner reveals details of how the protein binds to chromosomes and could offer insights for future disease treatments. The protein - BRD4 - plays a critical role in how cells read, copy and repair DNA and helps determine how different kinds of cells are made; it has been linked to many types of cancers and is considered a promising target for future therapies. The study, led by scientists at Penn State, and published in the journal Molecular Cell, found that BRD4 can attach to DNA-packaging structures in cells even without a molecular signal long belie...