India, Sept. 17 -- The Detroit Lions have run into serious trouble ahead of their high-voltage Thursday Night Football showdown against the Buffalo Bills, losing two crucial offensive linemen to injury. Right tackle Blake Miller and left guard Christian Mahogany have officially been ruled out for the Week 2 contest at Highmark Stadium. With Jared Goff heading into a hostile road atmosphere without two primary protectors, Dan Campbell's men face a massive test against Buffalo's ferocious front four.

Major Offensive Line Shake-Up For Detroit

Blake Miller has been sidelined due to a knee injury, while Christian Mahogany will miss the trip after failing to overcome a hip issue. Both starters play an integral part in establishing Detroit's r...