ISLAMABAD, April 12 -- High-level talks between the United States and Iran concluded without an agreement after nearly 21 hours of negotiations in Islamabad, US Vice President JD Vance said.

Vance described the discussions as substantive but said no deal could be reached, citing Washington's demand for a clear and long-term commitment from Tehran to refrain from pursuing nuclear weapons or capabilities enabling rapid weaponisation. He said the US approach was flexible and in good faith, but Iran did not accept the proposed terms. A "final and best offer" has now been presented, with the US awaiting Iran's response.

Earlier, Iran indicated that dialogue would continue despite unresolved differences, calling the meeting the highest-level ...