New Delhi, July 8 -- Major U.S. stock indexes fell sharply on Wednesday as renewed tensions in the Middle East triggered fresh concerns among investors following President Donald Trump's announcement that an interim ceasefire agreement with Iran had collapsed.

At 12:04 p.m. ET, the Dow Jones Industrial Average fell 774.50 points, or 1.46%, to 52,150.65, the S&P 500 lost 66.94 points, or 0.89%, to 7,437.21 and the Nasdaq Composite lost 235.63 points, or 0.91%, to 25,584.18.

At 10:10 a.m. ET, the Dow Jones Industrial Average fell 514.42 points, or 0.97%, to 52,410.73, the S&P 500 lost 34.32 points, or 0.46%, to 7,469.53 and the Nasdaq Composite lost 78.12 points, or 0.31%, to 25,739.43.

At the opening bell, the Dow Jones Industrial Avera...