New Delhi, Sept. 25 -- San Francisco 49ers star defensive end Nick Bosa pulled his calf in Thursday's practice and is set to miss Sunday's NFC West game against the Arizona Cardinals.

The five-time Pro Bowler will not play in Week 3 as the 49ers weigh whether to place him on injured reserve. An IR move would keep him out at least four games and use one of the club's limited return designations.

Nick Bosa spent the offseason recovering from a torn ACL in his right knee, an injury suffered last season in Week 3 against these same Cardinals. This Sunday would have been almost exactly a year later.

He returned for the start of 2026 and played 70 snaps across San Francisco's first two games. On Wednesday, he was listed as a non-participant ...