ISLAMABAD, April 11 -- Pakistan is set to host talks between Iran and the United States in a bid to turn a fragile two-week ceasefire into a lasting end to a war that has left thousands dead and roiled global energy markets.

Here are five things to know about the Islamabad talks:

 The war behind the talks 

On February 28, the United States and Israel launched deadly coordinated strikes that killed supreme leader Ali Khamenei and struck Iran's military and nuclear infrastructure.

More than 3,000 people were killed in Iran in five weeks, according to Iranian media and US-based Human Rights Activists News Agency (HRANA).

Tehran responded by effectively closing the Strait of Hormuz, the Gulf waterway through which about a fifth...