MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202617090465 A) filed by Amgen Inc. on July 24, 2026, for Methods For Modulating Monoclonal Antibody Charge Variants.
Inventors include Cairns, Grant J.; and Tan, Li Xuan.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to methods of modulating the charge variant profile of a recombinantly produced monoclonal antibody by altering bioreactor media hold durations. Methods of increasing product yield and titer by manipulating media hold durations are also described.
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